Last edited by Arashile
Tuesday, October 6, 2020 | History

5 edition of Structure-activity relationship analysis of Chinese anticancer drugs and related plants found in the catalog.

Structure-activity relationship analysis of Chinese anticancer drugs and related plants

by Eric J. Lien

  • 16 Want to read
  • 31 Currently reading

Published by Oriental Healing Arts Institute in Long Beach, CA., U.S.A .
Written in English

    Subjects:
  • Pharmacognosy.,
  • Neoplasms -- drug therapy.,
  • Antineoplastic Agents -- therapeutic use.,
  • Medicine, Chinese Traditional.,
  • Plants, Medicinal.,
  • Materia Medica.,
  • Herbal Medicine, Chinese.,
  • Pharmacognosy.,
  • Neoplasms -- herbal therapy, Chinese.,
  • Neoplasms -- drug therapy.,
  • Antineoplastic Agents -- therapeutic use.,
  • Medicine, Chinese Traditional.,
  • Plants, Medicinal.,
  • Materia medica.

  • Edition Notes

    Other titlesChung yao kang yen chi hua hsueh kou tsao chih kunan lien, Anticancer--Chinese drugs
    Statementby Eric J. Lien and Wen Y. Li.
    ContributionsLi, Wen Y.
    The Physical Object
    Paginationx, 150 p. :
    Number of Pages150
    ID Numbers
    Open LibraryOL19293154M
    ISBN 10094194218X
    LC Control Number09616822
    OCLC/WorldCa13271024

    Results: A total of 95 related references were found. The phytochemicals, fractions and extracts are grouped by their general classes or by their putative active components. More than 90 bioactive anti-biofilm compounds have been identified from different parts of the by: 9.   The models were then used to understand the factors that govern the anticancer activity of molecules under consideration, with the goal to identify potential drugs from plants. They used a data set of compounds screened for their in vitro anticancer activity in Cited by:

    The book lists drugs, described for the first time with drawings. Structure activity relationship. This has resulted in new developments in the area of combinatorial chemistry, new advances in the analysis and assaying of plant materials and a heightened awareness of the potential plant materials as drug leads by. by has it that about 80% of drugs were either Natural Products (NPs) or analogues inspired by them. According to a recent review on new chemical entities by Newman and Cragg, ~49% of anticancer drugs were either natural products or natural product-related synthetic compounds or their mimetics (Newman and Cragg, ).

    There has been increasing interest in the research on flavonoids from plant sources because of their versatile health benefits reported in various epidemiological studies. Since flavonoids are directly associated with human dietary ingredients and health, there is need to evaluate structure and function relationship. The bioavailability, metabolism, and biological activity of flavonoids depend. The journal publishes pre-clinical and clinical studies on the development of new anti-cancer agents. Clinical studies of new reported anti-cancer drugs include Phase 1–IV clinical trial studies, their designs, research methodologies, and analyses. The journal is essential reading to clinical oncologists, toxicologists, medicinal chemists, and to pharmacologists.


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Structure-activity relationship analysis of Chinese anticancer drugs and related plants by Eric J. Lien Download PDF EPUB FB2

Structure-activity relationship analysis of Chinese anticancer drugs and related plants. Long Beach, CA., U.S.A.: Oriental Healing Arts Institute, [©] (OCoLC) Online version: Lien, Eric J., Structure-activity relationship analysis of Chinese anticancer drugs and related plants. Among the anticancer drugs, about 50% come from natural products as isolated or semisynthetic or related synthetic compounds and plants represent important source of these substances.

Taxol, vinca alkaloids, camptothecin, and podophyllotoxins, as well as their semisynthetic or synthetic derivatives, are the most important anticancer drugs Cited by: 4.

We performed a structure-activity relationship (SAR) study of a novel aspirin (ASA) derivative, which shows strong anticancer activity in vitro and in vivo.A series of ASA-based benzyl esters (ABEs) were synthesized and their inhibitory activity against human colon (HT and SW) and pancreatic (BxPC-3 and MIA PaCa-2) cancer cell lines was evaluated.

Structure Activity Relationship Analysis of Anticancer Chinese Drugs and Related Plants. Structure Activity Relationship Analysis of Anticancer Chinese Drugs and Related Plants. Reference: Author: LIEN E.

J., WEN Y. Li In this timely book Professor Eric J. Lien and his assistant Wen Y. Li, both working in biomedicinal. Author(s): Lien,Eric J,; Li,Wen Y Title(s): Structure-activity relationship analysis of Chinese anticancer drugs and related plants/ by Eric J.

Lien and Wen Y. Flavonoids as Anticancer Agents: Structure-Activity Relationship Study Article Literature Review in Current Medicinal Chemistry - Anti-Cancer Agents 2(6) December with ReadsAuthor: Miguel López-Lázaro. I would like to ask for your help, regarding the structure activity relationship of the Erythrina type alkaloids and anticancer (Cell lines: HeLa, Hep-G2, HEP-2, HCT, MCF-7 and HFB4), I see.

Sophoridine (1), a natural anticancer drug, has been used in China for decades.A series of novel N-substituted sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure–activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer by: Isolation, Synthesis and Structure −−−−Activity Relationship Study of Anticancer and Antimalarial Agents from Natural Products Yumin Dai Dissertation submitted to the faculty of Virginia Polytechnic Institute and State University in partial fulfillment of the requirements.

We performed a structure-activity relationship (SAR) study of a novel aspirin (ASA) derivative, which shows strong anticancer activity in vitro and in vivo. A series of ASA-based benzyl esters (ABEs) were synthesized and their inhibitory activity against human colon (HT and SW) and pancreatic (BxPC-3 and MIA PaCa-2) cancer cell lines was.

Lien E and Wen L, Structure Activity Relationship Analysis of Chinese Anti-Cancer Drugs and Related Plants, Oriental Healing Arts Institute, Long Beach, CA.

Chang HM and But PPH (editors), Pharmacology and Applications of Chinese Materia Medica, (2 vols.), World Scientific, Singapore. Naturally occurring compounds such as secondary metabolites from plants play a significant role in the development of anticancer drugs.

The majority of synthetic drugs used in the treatment of cancer are cytotoxic in nature and they work by interfering with the structure and functions of the cellular by: 2. BackgroundXanthone derivatives have a wide range of pharmacological activities, such as those involving antibacterial, antiviral, antimalarial, anthelmintic, anti-inflammatory, antiprotozoal, and anticancer properties.

Among these, we investigated the anticancer properties of xanthone. This research aimed to analyze the biological activity of ten novel xanthone derivatives, to investigate the. Structure Activity Relationship Analysis of Chinese Anti-Cancer Drugs and Related Plants by Eric Lien and Wen Li (Oriental Healing Arts Institute, ) Icones of Medicinal Fungi from China by Ying Jianzhe, et al.

(Science Press, Beijing, ). The history of herbal medication is as recent as human civilization. Herbal medicines, as the major remedy in ancient system of medicine, are employed in medical practices since antiquity [2, 3].The early medicines of Pharaohs ( BC), the Greek (– BC; Hippocratis), the Roman (37 BC; Disoscorides, a Greek physician of the first century AD was the writer of the first Materia Medica Author: Shagufta Perveen, Areej Mohammad Al-Taweel.

Loa, J., Chow, P. & Zhang, K. Studies of structure-activity relationship on plant polyphenol-induced suppression of human liver cancer cells.

Cancer Chemotherapy and Pharmacol – Cited by: Structure-activity relationships of the antimalarial agent artemisinin. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and deoxoartemisinin.

Natural compounds isolated from Chinese medicines represent a large reservoir of potential leads for drug discovery. We have previously summarized the anticancer activities and mechanisms of action of terpenoids [], quinones [], and alkaloids [] which have shown promising medicinal naturally derived compounds, such as taxol and vincristine, have long been widely used as Cited by: Utilizing a pharmacophore hybridization approach, we have designed and synthesized a novel series of 28 new heterobivalent β-carbolines.

The in vitro cytotoxic potential of each compound was evaluated against the five cancer cell lines (LLC, BGC, CT, Bel, and MCF-7) of different origin—murine and human, with the aim of determining the potency and selectivity of the by: 1. The present study was carried out to evaluate the anticancer, antioxidant, and possible anti-inflammatory properties of diverse medicinal plants frequently used in Indian traditional medication.

The selected botanicals such as Soymida fembrifuga (Roxb.) A. Juss. (Miliaceae), Tinospora cordifolia (Willd.) by:. Title:Phytochemicals in Anticancer Drug Development VOLUME: 19 ISSUE: 2 Author(s):Rohit Dutt, Vandana Garg, Naveen Khatri and Anil K.

Madan* Affiliation:Department of Pharmacy, G.D. Goenka University, Gurgaon, Department of Pharmaceutical Sciences, M. D. University, Rohtak, Faculty of Pharmaceutical Sciences, Pt. B. D. Sharma University of Health Sciences Rohtak-Cited by: 4.Taxane Analogues against Breast Cancer: A Quantitative Structure–Activity Relationship Study Rajeshwar P.

Verma, Corwin Hansch ChemMedChem 3 (4), Cited by: The first structure-activity relationship, which was developed by Paul Ehrlich in the first decade of the 20th century, involved the development of the inorganic compound arsphenamine (otherwise known as Salvarsan or Ehrlich ) as a successful treatment for syphilis.

Ehrlich was the founder of chemotherapy, which he defined.